1374582-50-9

Upstream product

• 3143-02-0 3-hydroxymethyl-3-methyloxethane 
• 1374582-46-3 (R)-2-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)propanal 
• 1374582-49-6 C₉H₁₆O₄ 
• 824-94-2 p-methoxybenzyl chloride 
• 1374582-47-4 (3-methyloxetan-3-yl)methyl 2-bromopropionate 
• 1374582-48-5 1-(1-bromoethyl)-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 96536-76-4 1-vinyl-4-methyl-2,6,7-trioxabicyclo<2.2.2>octane 

Relevant academic research and scientific papers

Synthesis of the Prelog-Djerassi lactone via an asymmetric hydroformylation/crotylation tandem sequence

A synthesis of the Prelog-Djerassi lactone [(+)-1] has been accomplished in three isolations and 57% overall yield from the known vinyl ortho ester 2. A Rh(I)-catalyzed asymmetric hydroformylation/crotylation tandem sequence has been developed and used to set the C2-C4 stereochemistry. A Rh(I)-catalyzed asymmetric hydrogenation was employed to set the C6 sterechemistry, resulting in an unusually short and efficient enantioselective synthesis of this touchstone molecule from achiral starting material.