1374584-60-7Relevant academic research and scientific papers
Combined heterogeneous metal/chiral amine: Multiple relay catalysis for versatile eco-friendly synthesis
Deiana, Luca,Jiang, Yan,Palo-Nieto, Carlos,Afewerki, Samson,Incerti-Pradillos, Celia A.,Verho, Oscar,Tai, Cheuk-Wai,Johnston, Eric V.,C?rdova, Armando
, p. 3447 - 3451 (2014/04/03)
Herein is described a versatile and broad synergistic strategy for expansion of chemical space and the synthesis of valuable molecules (e.g. carbocycles and heterocycles), with up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols (31 examples, 95:5 to >99.5:0.5 e.r.) using integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O2 as the terminal oxidant. A novel highly 1,4-selective heterogeneous metal/amine co-catalyzed hydrogenation of enals was also added to the relay catalysis sequences. Relay switch: A versatile strategy for expansion of chemical space and the synthesis of valuable molecules, having up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols is described. The method employs integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O2 as the terminal oxidant.
Concise catalytic asymmetric total synthesis of biologically active tropane alkaloids
Cordova, Armando,Lin, Shuangzheng,Tseggai, Abrehet
, p. 1363 - 1372 (2012/06/18)
A general strategy for the total asymmetric synthesis of valuable tropane alkaloids by catalytic stereoselective transformations is disclosed. The power of this approach is exemplified by the concise catalytic enantioselective total syntheses of (+)-methylecgonine, (-)-cocaine and (+)-cocaine as well as the first catalytic asymmetric total syntheses of a cocaine C-1 derivative and (+)-ferruginine starting from 5-oxo-protected-α,β-unsaturated enals using only two and three column chromatographic purification steps, respectively. Copyright
