1374586-83-0Relevant academic research and scientific papers
Rotamers or diastereomers? An overlooked NMR solution
Hu, Dennis X.,Grice, Peter,Ley, Steven V.
, p. 5198 - 5202 (2012)
The existence of rotamers in a solution of analyte complicates 1H NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments, changing NMR solvents, or adding complexing agents. Here, with specific examples, we illustrate the use of simple yet widely overlooked chemical-exchange NMR experiments which allow the nonintrusive rapid distinguishment of rapidly equilibrating small molecules such as rotamers from nonequilibrating diastereomers.
