1374601-40-7

Basic information

• Product Name: BRD4770
• Synonyms: BRD4770;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester
• CAS NO: 1374601-40-7
• Molecular Formula: C25H23N3O3
• Molecular Weight: 413.46842
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 1374601-40-7.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble5mg/mL, clear (warmed)
• PKA: 12.12±0.43(Predicted)
• CAS DataBase Reference: BRD4770(CAS DataBase Reference)
• NIST Chemistry Reference: BRD4770(1374601-40-7)
• EPA Substance Registry System: BRD4770(1374601-40-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1374601-40-7(Hazardous Substances Data)

Usage

Uses

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]

Biochem/physiol Actions

BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.