1374641-74-3Relevant articles and documents
Deuterated pyrimidine derivative with anti-cancer effect
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Paragraph 0071; 0099-0103, (2020/07/21)
The invention relates to a deuterated pyrimidine derivative with an anti-cancer effect, and belongs to the field of medicines. The invention aims to solve the problems that the in-vivo half-life period of an anti-cancer drug WZ4002 is too short, the blood
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer
Han, Chun,Huang, Zhangjian,Zheng, Chao,Wan, Ledong,Zhang, Lianwen,Peng, Sixun,Ding, Ke,Ji, Hongbin,Tian, Jide,Zhang, Yihua
, p. 4738 - 4748 (2013/07/19)
A series of hybrids (12a-k) from (phenylsulfonyl)furoxan and anilinopyrimidine were synthesized and biologically evaluated as epidermal growth factor receptor (EGFR) inhibitors for intervention of non-small-cell lung cancer (NSCLC). Compound 12k exhibited