1374754-35-4

Upstream product

• 605-65-2 5-(dimethylamino)naphth-1-ylsulfonyl chloride 
• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 1374754-40-1 C₂₉H₃₅NO₅SSi 
• 1374754-39-8 C₃₅H₄₉NO₅SSi₂ 
• 1374754-36-5 C₂₃H₂₁NO₅S 
• 1374754-38-7 C₂₆H₂₅NO₅S 
• 1374754-37-6 2,2-dimethyl-4H-naphtho[2,3-d][1,3]dioxin-9-ol 
• 1374754-44-5 C₃₅H₃₇N₃O₉S 
• 1334590-39-4 8-hydroxy-3-(hydroxymethyl)naphthalen-2-ol 

Downstream Products

• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 

Relevant academic research and scientific papers

Bichromophoric fluorescent photolabile protecting group for alcohols and carboxylic acids

Novel bichromophoric fluorescent photolabile protecting group, (5-dansyloxy-3-hydroxynaphthalen-2-yl)methyl (DNS-NQMP), allows for the independent photochemical release and fluorescent imaging of caged substrates. Irradiation of DNS-NQMP-caged alcohols and carboxylic acids with 300 or 350 nm light results in fast (krelease ～ 105 s-1), efficient (Φ = 0.2), and quantitative release of the substrates. This uncaging chemistry is compatible with aqueous media and DNS-NQMP-protected hydroxy compounds are hydrolytically stable at neutral pH. Upon excitation with 400 nm light, caged compounds show intense green emission (λ max = 559 nm) with 21% fluorescence quantum yield. Fluorescent readout conducted using 400 nm or longer wavelengths does not cause substrate release. The DNS-NQMP chromophore retains its fluorescent properties after photo-uncaging reaction.