1374758-60-7Relevant academic research and scientific papers
METHOD OF PREPARING CHIRAL KETONES FROM ALDEHYDES
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Paragraph 0076; 0078; 0079, (2013/07/05)
Present invention relates to a method of preparing a chiral α- or β-substituted ketone from the corresponding β- or γ-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), re
Facile access to chiral ketones through metal-free oxidative C-C bond cleavage of aldehydes by O2
Tiwari, Bhoopendra,Zhang, Junmin,Chi, Yonggui Robin
supporting information; experimental part, p. 1911 - 1914 (2012/04/23)
Giving the metal the boot: The title reaction provides facile access to functionalized chiral ketones from chiral α,α′-disubstituted aldehydes in the presence of molecular oxygen (see scheme). The C-C bond-cleavage approach offers an alternative or better method relative to the typical bond-forming strategies used in synthesizing chiral ketones.
