1374759-46-2Relevant academic research and scientific papers
Photochemical generation and reactivity of the major hydroxyl radical adduct of thymidine
San Pedro, Joanna Maria N.,Greenberg, Marc M.
, p. 2866 - 2869 (2012/08/14)
5,6-Dihydro-5-hydroxythymidin-6-yl radical (1), the major reactive intermediate resulting from hydroxyl radical addition to C5 of the pyrimidine, is produced via 350 nm photolysis of a 2,5-dimethoxyphenylsulfide precursor (2). Competition between O2 and thiol for 1 suggests that the radical reacts relatively slowly with β-mercaptoethanol compared to other alkyl radicals. Overall, aryl sulfide 2 should be an effective precursor for the major hydroxyl radical adduct of thymidine in DNA.
