1374761-75-7Relevant academic research and scientific papers
Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents
Noncovich, Alain,Priest, Chad,Ung, Jane,Patron, Andrew P.,Servant, Guy,Brust, Paul,Servant, Nicole,Faber, Nathan,Liu, Hanghui,Gonsalves, Nicole S.,Ditschun, Tanya L.
, p. 3931 - 3938 (2017/07/27)
The paper presents the activity trends for a novel series of phenoxyacetyl amides as human TRPM8 receptor agonists. This series encompasses in vitro activity values ranging from the micromolar to the picomolar levels. Sensory evaluation of these molecules highlights their relevance as cooling agents for oral applications. The positive outcome of the complete evaluation of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide resulted in its approval for Generally Recognized As Safe (GRAS) status by the Flavor & Extract Manufacturer Association (FEMA) as FEMA 4809.
COMPOUNDS USEFUL AS MODULATORS OF TRPM8
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Page/Page column 82; 83, (2012/05/20)
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particul
