1374772-02-7Relevant articles and documents
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease
Trapero, Ana,González-Bulnes, Patricia,Butters, Terry D.,Llebaria, Amadeu
supporting information; experimental part, p. 4479 - 4488 (2012/08/14)
Amino-myo-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase (GCase), the β-glucosidase enzyme deficient in Gaucher disease (GD). When tested using lymphoblasts derived from patients with GD homozygous for N370S or L444P mu