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Upstream product

• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 104-87-0 4-methyl-benzaldehyde 
• 67-52-7 BARBITURIC ACID 

Relevant academic research and scientific papers

One-pot synthesis of pyrido[2,3-d:5,6-d′]dipyrimidines using CoFe2O4@SiO2-PA-CC-guanidine-SA magnetic nanoparticles in water

In this study, the synthesis of pyrido[2,3-d:5,6-d′]dipyrimidines using CoFe2O4@SiO2-PA-CC-guanidine-SA magnetic nanoparticles with excellent yields has been reported. Pyrido[2,3-d:5,6-d′]dipyrimidines were synthesized fro

Immobilization of Cu(II)on MWCNTs@L-His as a new high efficient reusable catalyst for the synthesis of pyrido[2,3-d:5,6-d′]dipyrimidine derivatives

In this research, a new heterogeneous organometallic catalyst was prepared through Cu(II)Immobilization on L-Histidine Functionalized multi-walled carbon nanotubes (MWCNTs@L-His/Cu(II)). Catalyst was prepared using a simple method and characterized by Fou

N-propylbenzoguanamine sulfonic acid-functionalized magnetic nanoparticles: A novel and magnetically retrievable catalyst for the synthesis of 1,4-dihydropyridine derivatives

The catalytic activity of N-propylbenzoguanamine sulfonic acid stabilized on silica-coated nano-Fe3O4 particles (Fe3O4/SiO2-N-propyl-benzoguanamine-SO3H) were proven to be as a novel magnet

DIPEAc promoted one-pot synthesis of dihydropyrido[2,3-: D:6,5- d ′]dipyrimidinetetraone and pyrimido[4,5- d] pyrimidine derivatives as potent tyrosinase inhibitors and anticancer agents: In vitro screening, molecular docking and ADMET predictions

The present method provides a wide scope and quick access to dihydropyrido[2,3-d:6,5-d′]dipyrimidinetetraone and pyrimido[4,5-d]pyrimidine derivatives in good to excellent isolated yields from a one-pot three-component reaction of aldehydes, barbituric acid and ammonium acetate/urea in DIPEAc at room temperature. Major advantages of the present methodology are: use of green solvent, short reaction time, catalyst free, compatibility with a wide range of substrates, ease of recovery, reusability of the reaction medium, and DIPEAc as an alternative solvent and catalyst. All the synthesized compounds (3a-k) and (4a-g) were evaluated for their in vitro anticancer and tyrosinase inhibitory activity. In vitro anticancer screening of the synthesized compounds was performed against MCF-7, HeLa and A-549 cancer cell lines and 3f, 3h and 3i showed good activity. The compounds 3a, 3c, 3f and 3i showed good in vitro anticancer activity against SK-MEL-2. The synthesized compounds were also tested on non-tumorigenic MCF-10A cell lines and were found to be selective towards their cancer cell lines. At the IC50 concentration of compound 3f there were typical morphological changes such as cell wall deformation, cell detachment, cell shrinkage and a reduced number of viable cells in MCF-7 cancer cell lines in comparison to control cells. Among the series, compounds 3f, 3h and 3i excellently inhibited the tyrosinase enzyme. A molecular docking study of the compounds was also performed and compounds showed overall very effective binding modes and good agglomeration in the active site by forming various interactions with active site residues. The in silico ADMET properties of the synthesized compounds showed that they possess worthy oral drug like properties.

Efficient sonochemical protocol for the facile synthesis of dipyrimido-dihydropyridine and pyrimido[4,5-d]pyrimidines in aqueous β-cyclodextrin

An economical and efficient synthesis of dipyrimido-dihydropyridines and pyrimido[4,5-d]pyrimidines is described using greener and recyclable β-cyclodextrin as a supramolecular catalyst in aqueous medium. The remarkable features of this method are mild reaction conditions, short reaction times, easy workup procedure, recyclability of the catalyst, and excellent yields of the products. The highly functional group tolerance and shorter reaction times make this method suitable for the synthesis of dihydropyridine and pyrimido[4,5-d]pyrimidine derivatives with a wide substitution pattern.

An efficient, one-pot synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines using SBA-15-supported sulfonic acid nanocatalyst under solvent-free conditions

Abstract An acidic nanocatalyst SBA-15-SO3H with a high surface area and high acid content was readily synthesized, characterized, and effectively used in the synthesis of some new and known pyrido[2,3-d:6,5-d′]dipyrimidine derivatives by conde

Catalyst-free synthesis of dihydropyridine from barbituric acid in water

An operationally simple, atom-economical, and green procedure has been developed for the synthesis of dihydropyridine derivatives by a simple condensation of barbituric acid, aldehyde, and ammonium acetate in water under catalyst-free conditions. Excellen