1374789-71-5Relevant academic research and scientific papers
Asymmetric organocatalytic synthesis of β-hydroxyynones with a quaternary carbon center under aqueous conditions
Kang, Guowei,Jiang, Jun,Liu, Hongxin,Wu, Huayue
scheme or table, p. 5 - 10 (2012/03/27)
The chiral tertiary amine thiourea catalyzed direct aldol reaction of unmodified methyl ynones under aqueous conditions is described. This procedure avoided the retro-aldol reaction of the βhydroxyynone products,and tolerated both the isatin (1H-indole-2,3-dione)the less active acyclic αketo esters as acceptors, affording a structurally diverse array of β-hydroxyynones bearing a quaternary carbon center with moderate to good yields and enantioselectivities.
