Cas 1374847-69-4,2-[({2-[(1-{[4-({6-[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R, 5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-[(phosphonooxy)methyl]oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hy-droxyoxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy} (hydroxy)phosphoryl)oxy]hexyl}carbamoyl)cyclohexyl]methyl}-2,5-dioxopyrrolidin-3-yl)sulfanyl]-1-carboxyethyl}carbamoyl)amino]pentanedioic acid

1374847-69-4

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Product Name: 2-[({2-[(1-{[4-({6-[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R, 5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-[(phosphonooxy)methyl]oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hy-droxyoxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy} (hydroxy)phosphoryl)oxy]hexyl}carbamoyl)cyclohexyl]methyl}-2,5-dioxopyrrolidin-3-yl)sulfanyl]-1-carboxyethyl}carbamoyl)amino]pentanedioic acid
Synonyms:
CAS NO:1374847-69-4
Molecular Formula:
Molecular Weight: 1698.32
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 2-[({2-[(1-{[4-({6-[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R, 5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-[(phosphonooxy)methyl]oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hy-droxyoxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy} (hydroxy)phosphoryl)oxy]hexyl}carbamoyl)cyclohexyl]methyl}-2,5-dioxopyrrolidin-3-yl)sulfanyl]-1-carboxyethyl}carbamoyl)amino]pentanedioic acid(CAS DataBase Reference)
NIST Chemistry Reference: 2-[({2-[(1-{[4-({6-[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R, 5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-[(phosphonooxy)methyl]oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hy-droxyoxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy} (hydroxy)phosphoryl)oxy]hexyl}carbamoyl)cyclohexyl]methyl}-2,5-dioxopyrrolidin-3-yl)sulfanyl]-1-carboxyethyl}carbamoyl)amino]pentanedioic acid(1374847-69-4)
EPA Substance Registry System: 2-[({2-[(1-{[4-({6-[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R, 5R)-2-(6-amino-9H-purin-9-yl)-5-{[({[(2R,5R)-2-(6-amino-9H-purin-9-yl)-4-hydroxy-5-[(phosphonooxy)methyl]oxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hy-droxyoxolan-3-yl]oxy}(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxy} (hydroxy)phosphoryl)oxy]hexyl}carbamoyl)cyclohexyl]methyl}-2,5-dioxopyrrolidin-3-yl)sulfanyl]-1-carboxyethyl}carbamoyl)amino]pentanedioic acid(1374847-69-4)

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Hazardous Substances Data: 1374847-69-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1374847-69-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,4,8,4 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1374847-69:
(9*1)+(8*3)+(7*7)+(6*4)+(5*8)+(4*4)+(3*7)+(2*6)+(1*9)=204
204 % 10 = 4
So 1374847-69-4 is a valid CAS Registry Number.

1374847-69-4Upstream product

1374847-68-3 {[(2R,5R)-5-(6-amino-9H-purin-9-yl)-4-[({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-4-[({[(2R,5R)-5-(6-amino-9H-purin-9-yl)-4-[({[6-({4-[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexyl}formamido)hexyl]oxy}(hydroxy)phosphoryl)-oxy]-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid

1374847-69-4Downstream Products

1374847-69-4Relevant academic research and scientific papers

Structure-activity relationships of 2′,5′-oligoadenylate analogue modifications of prostate-specific membrane antigen (PSMA) antagonists

Wang, Xinning,Tian, Haibin,Lee, Zhenghong,Heston, Warren D. W.

experimental part, p. 432 - 444 (2012/08/14)

□ Prostate-specific membrane antigen (PSMA) is an ideal biomarker for prostate cancer. A previously reported 2-5A conjugate RBI1033 (3) showed binding affinity more than 10 times higher than the parent urea-based compound (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido) pentanedioic acid (1). The purpose of this work is to further optimize the structure of 3 to identify highly selective ligands of PSMA. It was found that conjugates having 2-5A in their structure showed extraordinary improved binding affinity to PSMA compared with compound 1. Removal of 2-5A significantly reduced its biological activity. The results will provide a path to agents for targeted imaging and treatment of prostate cancer. Copyright Taylor and Francis Group, LLC.

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