1374858-57-7Relevant articles and documents
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model
Banerjee, Abhisek,Patil, Sandip,Pawar, Mahesh Y.,Gullapalli, Srinivas,Gupta, Praveen K.,Gandhi, Maulik N.,Bhateja, Deepak K.,Bajpai, Malini,Sangana, Ramachandra Rao,Gudi, Girish S.,Khairatkar-Joshi, Neelima,Gharat, Laxmikant A.
, p. 6286 - 6291 (2012)
The synthesis and structure-activity relationship studies of a series of compounds from imidazopyridazinone scaffold as PDE7 inhibitors are disclosed. Potent analogs such as compounds 7 (31 nM), 8 (27 nM), and 9 (12 nM) were identified. The PDE selectivit
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
Banerjee, Abhisek,Yadav, Pravin S.,Bajpai, Malini,Sangana, Ramachandra Rao,Gullapalli, Srinivas,Gudi, Girish S.,Gharat, Laxmikant A.
scheme or table, p. 3223 - 3228 (2012/06/18)
The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod