1374858-65-7Relevant academic research and scientific papers
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines
Fallacara, Anna Lucia,Passannanti, Raffaele,Mori, Mattia,Iovenitti, Giulia,Musumeci, Francesca,Greco, Chiara,Crespan, Emmanuele,Kissova, Miroslava,Maga, Giovanni,Tarantelli, Chiara,Spriano, Filippo,Gaudio, Eugenio,Bertoni, Francesco,Botta, Maurizio,Schenone, Silvia
, (2019)
Abnormal activation of B-cell receptor (BCR) signaling plays a key role in the development of lymphoid malignancies, and could be reverted by the simultaneous inhibition of Lyn, Fyn and Blk, three members of the Src family kinase (SFK). Fyn and Blk are al
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
Banerjee, Abhisek,Yadav, Pravin S.,Bajpai, Malini,Sangana, Ramachandra Rao,Gullapalli, Srinivas,Gudi, Girish S.,Gharat, Laxmikant A.
scheme or table, p. 3223 - 3228 (2012/06/18)
The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod
