137487-98-0Relevant academic research and scientific papers
Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents
Bairwa, Ranjeet,Kakwani, Manoj,Tawari, Nilesh R.,Lalchandani, Jaya,Ray,Rajan,Degani, Mariam S.
supporting information; experimental part, p. 1623 - 1625 (2010/06/16)
In an attempt to identify potential new agents active against tuberculosis, 20 novel phenylacrylamide derivatives incorporating cinnamic acids and guanylhydrazones were synthesized using microwave assisted synthesis. Activity of the synthesized compounds was evaluated using resazurin microtitre plate assay (REMA) against Mycobacterium tuberculosis H37Rv. Based on empirical structure-activity relationship data it was observed that both steric and electronic parameters play major role in the activity of this series of compounds. Compound 7s (2E)-N-((-2-(3,4-dimethoxybenzylidene) hydrazinyl) (imino) methyl)-3-(4-methoxyphenyl) acrylamide showed MIC of 6.49 μM along with good safety profile of >50-fold in VERO cell line. Thus, this compound could act as a potential lead for further antitubercular studies.
Evaluation of the thiosemicarbazones of some aryl alkyl ketones and related compounds for anticonvulsant activities
Dimmock, J.R.,McColl, J.M.,Wonko, S.L.,Thayer, R.S.,Hancock, D.S.
, p. 529 - 534 (2007/10/02)
The thiosemicarbazone of acetophenone (1a) had been shown previously to afford protection against experimentally-induced seizures.This report describes the systematic chemical modification of 1a and the activities of these analogues in the maximal electro
