137491-99-7Relevant articles and documents
Synthesis of Arene Oxide and trans-Dihydrodiol Metabolites of Quinoline
Agarwal, Shiv K.,Boyd, Derek R.,Davies, R. Jeremy H.,Hamilton, Lynne,Jerina, Donald M.,et al.
, p. 1969 - 1974 (2007/10/02)
Racemic samples of 5,6-epoxy-5,6-dihydroquinoline (2) (quinoline 5,6-oxide) and 7,8-epoxy-7,8-dihydroquinoline (4) (quinoline 7,8-oxide) have been synthesised by two methods from the corresponding dihydroquinoline precursors. trans-5,6-Dihydroquinoline-5,6-diol (3) and trans-7,8-dihydroquinoline-7,8-diol (5) were obtained both by multi-step synthetic routes from the corresponding dihydroquinolines and by the direct base-catalysed hydration of the corresponding arene oxides (2) and (4).