137492-06-9Relevant articles and documents
Synthesis of naturally occurring naphthoquinone epoxides and application in the synthesis of β-lapachone
Claessens, Sven,Habonimana, Pascal,De Kimpe, Norbert
, p. 3790 - 3795 (2010)
Optimized epoxidation conditions of mono- and dialkylated naphthoquinones are presented. Based on the epoxidation protocol making use of H 2O2/Na2CO3, naphthoquinone epoxides are obtained in high yields. The optimized epoxidation conditions are applied in a short and high yielding synthesis of the pharmaceutically important β-lapachone.