1374964-71-2Relevant academic research and scientific papers
Novel cyclopropyl-indole derivatives as HIV non-nucleoside reverse transcriptase inhibitors
Hassam, Mohammad,Basson, Adriaan E.,Liotta, Dennis C.,Morris, Lynn,Van Otterlo, Willem A. L.,Pelly, Stephen C.
supporting information; experimental part, p. 470 - 475 (2012/09/22)
The HIV pandemic represents one of the most serious diseases to face mankind in both a social and economic context, with many developing nations being the worst afflicted. Due to ongoing resistance issues associated with the disease, the design and synthesis of anti-HIV agents presents a constant challenge for medicinal chemists. Utilizing molecular modeling, we have designed a series of novel cyclopropyl indole derivatives as HIV non-nucleoside reverse transcriptase inhibitors and carried out their preparation. These compounds facilitate a double hydrogen bonding interaction to Lys101 and efficiently occupy the hydrophobic pockets in the regions of Tyr181/188 and Val179. Several of these compounds inhibited HIV replication as effectively as nevirapine when tested in a phenotypic assay.
