1374966-83-2Relevant academic research and scientific papers
Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone
Hartwig, Jan,Kirschning, Andreas
, p. 3044 - 3052 (2016)
Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines
Girling, P. Ricardo,Batsanov, Andrei S.,Shen, Hong C.,Whiting, Andrew
supporting information; experimental part, p. 4893 - 4895 (2012/06/18)
Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.
