1374967-91-5

Upstream product

• 2050-51-3 3-dibutylaminopropanol 
• 111-92-2 dibutylamine 
• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 
• 106-41-2 4-bromo-phenol 
• 64010-38-4 1-bromo-4-(3-chloropropoxy)benzene 
• 121-43-7 Trimethyl borate 
• 627040-50-0 N-(3-(4-bromophenoxy)propyl)-N-butylbutan-1-amine 

Downstream Products

• 141626-36-0 dronedarone 

Relevant academic research and scientific papers

Convergent synthesis of dronedarone, an antiarrhythmic agent

We have developed a convergent synthesis of dronedarone, an antiarrhythmic agent. The key steps of the process are the construction of a benzofuran skeleton by iodocyclization and the carbonylative Suzuki-Miyaura cross-coupling for biaryl ketone formation. This synthetic route required only eight steps from 2-amino-4-nitrophenol in 23% overall yield.

Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives

The present invention relates to a process for the preparation of 3-aroyl-5-aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.

PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES

The present invention relates to a process for the preparation of 3-aroyl -5- aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.