1374970-29-2Relevant academic research and scientific papers
Discovery and profiling of a selective and efficacious syk inhibitor
Thoma, Gebhard,Smith, Alexander B.,Van Eis, Maurice J.,Vangrevelinghe, Eric,Blanz, Joachim,Aichholz, Reiner,Littlewood-Evans, Amanda,Lee, Christian C.,Liu, Hong,Zerwes, Hans-Günter
, p. 1950 - 1963 (2015/04/27)
We describe the discovery of selective and potent Syk inhibitor 11, which exhibited favorable PK profiles in rat and dog and was found to be active in a collagen-induced arthritis model in rats. Compound 11 was selected for further profiling, but, unfortunately, in GLP toxicological studies it showed liver findings in rat and dog. Nevertheless, 11 could become a valuable tool compound to investigate the rich biology of Syk in vitro and in vivo.
BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
-
Page/Page column 173-174, (2012/05/20)
The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
