1374997-07-5Relevant academic research and scientific papers
Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology
Shaw, Arthur Y.,Medda, Federico,Hulme, Christopher
, p. 1313 - 1315 (2012)
The following report describes novel methodology for the rapid synthesis of unique conformationally constrained norstatine analogs of potential biological relevance. A PADAM (Passerini reaction-Amine Deprotection-Acyl Migration reaction) sequence is followed by a TFA-mediated microwave-assisted cyclization to generate the final benzimidazole isostere of the norstatine scaffold in moderate to good yields. The applicability of this solution phase methodology to the preparation of a small collection of compounds is discussed.
