1374999-96-8

Basic information

• Product Name: 1',4',6',7'-tetrahydro-6'-(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)-1'-methyl-4'-[3-(acetic acid methyl ester)-2,4-dioxo-thiazolidin-5-yl]spiro[thiazolidine-5,5'-[5H]indazol]-2,3',4(2'H)-trione-3-acetic acid methyl ester
• Synonyms: 1',4',6',7'-tetrahydro-6'-(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)-1'-methyl-4'-[3-(acetic acid methyl ester)-2,4-dioxo-thiazolidin-5-yl]spiro[thiazolidine-5,5'-[5H]indazol]-2,3',4(2'H)-trione-3-acetic acid methyl ester
• CAS NO: 1374999-96-8
• Molecular Weight: 774.832
• Mol File: 1374999-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1',4',6',7'-tetrahydro-6'-(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)-1'-methyl-4'-[3-(acetic acid methyl ester)-2,4-dioxo-thiazolidin-5-yl]spiro[thiazolidine-5,5'-[5H]indazol]-2,3',4(2'H)-trione-3-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1',4',6',7'-tetrahydro-6'-(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)-1'-methyl-4'-[3-(acetic acid methyl ester)-2,4-dioxo-thiazolidin-5-yl]spiro[thiazolidine-5,5'-[5H]indazol]-2,3',4(2'H)-trione-3-acetic acid methyl ester(1374999-96-8)
• EPA Substance Registry System: 1',4',6',7'-tetrahydro-6'-(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)-1'-methyl-4'-[3-(acetic acid methyl ester)-2,4-dioxo-thiazolidin-5-yl]spiro[thiazolidine-5,5'-[5H]indazol]-2,3',4(2'H)-trione-3-acetic acid methyl ester(1374999-96-8)

Safety Data

• Hazardous Substances Data: 1374999-96-8(Hazardous Substances Data)

Upstream product

• 950-81-2 4-formyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 
• 1374999-90-2 methyl (Z)-2-{5-[(1,2-dihydro-1,5-dimethyl-3-oxo-2-phenyl-3H-pyrazol-4-yl)methylene]-2,4-dioxo-3-thiazolidine}acetate 

Relevant articles and documents

Synthesis and biological activities of some new thiazolidine derivatives containing pyrazole ring system

As a part of systematic investigation of synthesis and biologically active compounds of thiazolidine (TZD) derivatives containing pyrazole ring system, several new pyrazole-TZD derivatives 8a-d and 9a-d have been synthesized. Compounds 8a-d were prepared from N-substituted TZDs 6a-d and 1H-pyrazole-4-carboxaldehyde 7 by Knoevenagel-type reaction. Treatment of 8a-d with sodium hydride at room temperature caused dimerization reaction to afford the corresponding spirocompounds 9a-d. All the synthesized compounds were characterized by spectroscopic analysis. In vitro, the synthesized compounds 8a-d and 9a-d were tested for their growth inhibitory activity in A549 lung cancer, B16F10 murine melanoma, and HeLa human uterine carcinoma cells and for their differentiation of 3T3-L1 preadipocytes to adipocytes. The results showed that compound 8c possessed growth inhibitory effect of B16F10 cells (IC 50 = 27 μM) and compounds 9c,d had induction effect on the differentiation of 3T3-L1 preadipocytes. Copyright