1375007-98-9Relevant academic research and scientific papers
Ambient temperature zincation of N-Boc pyrrolidine and its solvent dependency
Garden, Jennifer A.,Kennedy, Alan R.,Mulvey, Robert E.,Robertson, Stuart D.
, p. 5265 - 5267 (2012)
Sodium TMP-zincate, [(TMEDA)Na(TMP)(tBu)Zn(tBu)], can deproto-zincate N-Boc pyrrolidine at ambient temperature in hexane solution, whereas in toluene the captured α-carbanion of the heterocycle attacks the solvent setting off a cascade of reactions that ultimately produce a pyrrolidine-substituted enolate.
