1375008-01-7Relevant academic research and scientific papers
Palladium-catalyzed carbonylative heck reaction of aryl bromides with vinyl ethers to 3-alkoxy alkenones and pyrazoles
Schranck, Johannes,Wu, Xiao-Feng,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 4827 - 4831 (2012/05/20)
Three COming together: The first carbonylative Heck coupling reaction of aryl bromides and vinyl ethers leading to 1-aryl-3-alkoxy-2-propen-1-ones has been established (see scheme). Based on this coupling methodology, a novel one-pot synthesis of aryl-substituted pyrazoles was also realized. Copyright
Palladium catalyzed carbonylative Heck reaction affording monoprotected 1,3-ketoaldehydes
Gogsig, Thomas M.,Nielsen, Dennis U.,Lindhardt, Anders T.,Skrydstrup, Troels
supporting information; experimental part, p. 2536 - 2539 (2012/08/14)
The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl methyl ketones. The presented strategy can also be adapted for the facile and efficient incorporation of 13C-labeled carbon monoxide.
