137504-86-0

Basic information

• Product Name: 4-Chloro-3-fluorobenzeneboronic acid
• Synonyms: 4-Chloro-3-fluorophenylboronic acid ,98%;4-Chloro-3-fluoroben;(4-chloro-3-fluorophenyl)boronic acid(SALTDATA: FREE);3-fluoro-4-Chlorophenylboronic acid;4-Chloro-3-fluorobenzeneboronic acid (contains varying aMounts of anhydride);dihydroxy(3-fluoro-4-chlorophenyl)-borane;4-Chloro-3-fluorophenylboronic Acid (contains varying aMounts of Anhydride);B-(4-chloro-3-fluorophenyl)-Boronic acid
• CAS NO: 137504-86-0
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• Product Categories: Aryl;Fluorinated;Organoborons;Boronic Acids & Esters;Phenyls & Phenyl-Het;blocks;BoronicAcids;FluoroCompounds;Boric Acid;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic Acid
• Mol File: 137504-86-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 198-204℃
• Boiling Point: 302.6 °C at 760 mmHg
• Flash Point: 136.8 °C
• Appearance: Off-white crystal
• Density: 1.41 g/cm³
• Vapor Pressure: 0.000434mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 7.31±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3-fluorobenzeneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-fluorobenzeneboronic acid(137504-86-0)
• EPA Substance Registry System: 4-Chloro-3-fluorobenzeneboronic acid(137504-86-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-36-39-60-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 137504-86-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Cryst

Uses

Different sources of media describe the Uses of 137504-86-0 differently. You can refer to the following data:
1. suzuki reaction
2. 4-?Chloro-?3-?fluorophenylboronic Acid is a useful synthetic compound.

InChI:InChI=1/C6H5BClFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H

Upstream product

• 121-43-7 Trimethyl borate 
• 60811-18-9 2-chloro-5-bromofluorobenzene 

Downstream Products

• 1292286-75-9 2-(4-chloro-3-fluorophenyl)-5,6-dimethyl-4-methoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1252036-36-4 3-(4'-chloro-3'-fluorobiphenyl-4-yl)-1-[(2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one 
• 1251464-86-4 6-(4-chloro-3-fluorophenyl)-1-methyl-N-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1194097-54-5 8-(4-chloro-3-fluorophenyl)-2-[(dimethylamino)methyl][1]benzothieno[3,2-d]pyrimidin-4(3H)-one 
• 1190735-30-8 C₂₀H₂₄ClFN₄O₄ 
• 1190735-35-3 C₁₆H₁₄ClFN₂O₃S 
• 1046158-87-5 2-butyl-3-(4-chloro-3-fluorophenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 503308-76-7 C₂₀H₁₃Cl₂F₂N₃S 
• 877169-04-5 4'-chloro-5,3'-difluoro-biphenyl-2-yl-amine 
• 136861-87-5 2-(4-Chloro-3-fluorophenyl)-5-(4-propylphenyl)-pyridine 

Relevant articles and documents

Preparation method of 4''-alkyl-2, 4, 3'-trifluoro-terphenyl liquid crystal monomer

The invention relates to the field of liquid crystal display, in particular to a preparation method of a 4''-alkyl-2, 4, 3'-trifluoro-terphenyl liquid crystal monomer for liquid crystal display. The preparation method comprises the following steps: taking 3-fluoro-4-chlorobromobenzene as a raw material, and preparing 3-fluoro-4-chlorophenylboronic acid through Grignard reaction; carrying out Suzuki coupling reaction on the 3-fluoro-4-chlorophenylboronic acid and 2, 4'-difluorobromobenzene to obtain a key intermediate 4'-chloro-2, 4, 3'-trifluoro-biphenyl; and carrying out Suzuki coupling reaction on the intermediate and 4-alkylphenylboronic acid to a to obtain the liquid crystal monomer. The synthesis route adopts cheap raw materials, a final product is prepared through conventional reactions, the production cost is low, large-scale production is facilitated, and the preparation method has a very high application prospect.