137524-65-3Relevant academic research and scientific papers
Efficient synthesis of resin-bound α-TMSdiazoketones and their use in solid-phase organic synthesis
Iso, Yasuyoshi,Shindo, Hirohisa,Hamana, Hiroshi
, p. 5353 - 5361 (2000)
α-TMSdiazoketones on a solid support could be simply and efficiently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These α-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids. (C) 2000 Elsevier Science Ltd.
