1375304-43-0Relevant articles and documents
An easy two step synthesis of macrocyclic peptidotriazoles via a four-component reaction and copper catalyzed intramolecular azide-alkyne [3+2] click cycloaddition
Bahulayan,Arun
supporting information; experimental part, p. 2850 - 2855 (2012/07/27)
A two-step macrocyclization strategy for the synthesis of 12- and 14-membered cyclic peptidotriazoles by combining a one pot four-component reaction and an intramolecular [3+2] azide-alkyne click cycloaddition reaction is described. Macrocycles are obtained in good to excellent yield from the aqueous work-up of the reaction mixture and it is possible to expand or contract the ring size by adjusting the length of the nitrile moiety used in the MCR stage.