137531-93-2

Upstream product

• 5497-67-6 2,2-dimethyl-4-pentenal 
• 3420-42-6 2,2-dimethylpent-4-en-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 114925-44-9 *S^*)>-α,2,2-trimethyl-1,3-dioxolane-4-acetaldehyde 
• 137531-87-4 (2S,3R,4R,5R,8S)-8-(m-benzyloxymethoxyphenyl)-1-(tert-butyldimethylsiloxy)-5-hydroxymethyl-8-methoxy-3-methyl-2-(2-tetrahydropyranyloxy)octan-4-ol 
• 137531-99-8 (2R,3R)-3-(m-benzyloxymethoxyphenyl)-2,3-epoxypropan-1-ol 
• 137532-01-5 (S)-3-(m-benzyloxymethoxyphenyl)-1-bromo-3-methoxypropane 
• 120506-06-1 isopropyl (2S,3R,4E)-6-benzyloxy-2-hydroxy-3-methyl-4-hexenoate 
• 137532-00-4 (S)-3-(m-benzyloxymethoxyphenyl)propane-1,3-diol 
• 137531-98-7 m-benzyloxymethoxycinnamyl alcohol 
• 137531-96-5 (3R,4R)-4-benzyloxymethoxy-3-hydroxy-1,1-propylenedithiopentane 
• 137531-86-3 (2S,3S,4S,5S)-6-(tert-butyldimethylsiloxy)-2,3-epoxy-4-methyl-5-(2-tetrahydropyranyloxy)hexan-1-ol 
• 137531-95-4 (2S,3R)-3-benzyloxymethoxy-1,2-carbonyldioxybutane 
• 14869-02-4 R-(E)-1-(benzyloxy)pent-3-en-2-ol 

Downstream Products

• 110330-12-6 (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester 
• 155433-69-5 Kishi's aldehyde 

Relevant academic research and scientific papers

A Formal Synthesis of Aplysiatoxin: Enantioselective Synthesis of Kishi's Aldehyde

This paper describes the enantioselective synthesis of key fragments (12,18,24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2).Since 2 has already been transformed into 1a in

A formal total synthesis of aplysiatoxin

A total synthesis of aplysiatoxin was achieved formally by construction of Kishi's intermediate 13 which carried all the stereochemistry required for the synthesis of aplysiatoxin, from four fragments described in the preceding communication.