1375415-39-6Relevant articles and documents
Stereoselective hydrofluorination of ynamides: A straightforward synthesis of novel α-fluoroenamides
Compain, Guillaume,Jouvin, Kevin,Martin-Mingot, Agnes,Evano, Gwilherm,Marrot, Jerome,Thibaudeau, Sebastien
, p. 5196 - 5198 (2012/06/01)
α-Fluoroenamides, potent rigid fluorinated bioisosters of ureas, have been synthesized by a highly regio- and stereo-selective hydrofluorination of ynamides in anhydrous HF. This reaction provides the first general entry to α-fluoroenamides and can easily be applied to a wide range of substrates.