137542-89-3

Upstream product

• 137623-80-4 (3S)-4,4-dimethyl-3-phenylpentanal 
• 83867-96-3 (+/-)-4,4-dimethyl-3-phenylpentanoic acid 
• 678991-35-0 E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-4,4-dimethylpent-2-enamide 
• 678991-36-1 E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-phenylprop-2-enamide 
• 137542-84-8 (S)-4-tert-Butyl-2-((S)-3,3-dimethyl-2-phenyl-butyl)-4,5-dihydro-oxazole 
• 137542-79-1 (4S)-4-tert-butyl-2-((E)-2-phenylethenyl)-2-oxazoline 
• 591-51-5 phenyllithium 
• 140-10-3 (E)-3-phenylacrylic acid 
• 105-38-4 vinyl propionate 
• 61136-73-0 (+/-)-4,4-dimethyl-3-phenyl-1-pentanol 
• 913962-67-1 (1'S,2'S,3S)-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N,4,4-trimethyl-3-phenylpentanamide 

Downstream Products

• 137542-93-9 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-4,4-dimethyl-3-phenyl-pentyl ester 

Relevant academic research and scientific papers

Lipase catalyzed acylation of primary alcohols with remotely located stereogenic centres: the resolution of (±)-4,4-dimethyl-3-phenyl-1-pentanol

Enantioselective acylation of some (±)-3-alkyl-3-phenyl-1-propanols was performed with enzymes as catalysts. Moderate enantiomeric ratios (E), ranging up to E = 11.6, were obtained. In the resolution, some of the lipases selectively acylated the (+)-enant

(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric conjugate addition and tandem conjugate addition/α-alkylation reactions

(Chemical Equation Presented) Organolithium reagents undergo highly regio- and diastereoselective 1,4-addition to (S,S)-(+)-pseudoephedrine enamides furnishing the corresponding β-alkyl-substituted adducts in excellent yields and diastereoselectivities. In addition, the intermediate lithium enolates generated after the conjugate addition step undergo a highly diastereoselective alkylation reaction, furnishing α,β-dialkyl- substituted amides in high yields. The obtained adducts have been converted into chiral nonracemic β-alkyl- and α,β-dialkyl-substituted carboxylic acids and γ-alkyl- and β,γ-dialkyl-substituted alcohols using very simple and high-yielding procedures.

Asymmetric Michael Additions to α,β-Unsaturated Oxazolines. An Efficient Preparation of Chiral β,β-Disubstituted Propionaldehydes

A short stereoselective route to a variety of chiral, nonracemic α,β-unsaturated oxazolines derived from (S)-tert-leucinol is described.Addition of organolithium reagents to this chiral oxazoline occurs in a Michael fashion, giving rise to adducts with hi