1375479-06-3Relevant academic research and scientific papers
Catalytic generation of arynes and trapping by nucleophilic addition and iodination
Hamura, Toshiyuki,Chuda, Yu,Nakatsuji, Yuya,Suzuki, Keisuke
supporting information; experimental part, p. 3368 - 3372 (2012/06/18)
A fair exchange: In the title reaction, alkynyllithium serves as an initiator for benzyne generation through an iodine-lithium exchange (see scheme; Tf=trifluoromethanesulfonyl). When performed in the presence of stoichiometric amounts of a nucleophile, the generated benzyne undergoes attack by lithio nucleophiles to generate aryllithium, which is then iodinated by iodoalkyne to give the iodoarenes 1. Copyright
