137552-29-5

Basic information

• Product Name: Uridine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-
• CAS NO: 137552-29-5
• Molecular Formula: C31H31N5O7
• Molecular Weight: 585.616
• Mol File: 137552-29-5.mol

Chemical Properties

• CAS DataBase Reference: Uridine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(137552-29-5)
• EPA Substance Registry System: Uridine, 5-(azidomethyl)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-(137552-29-5)

Safety Data

• Hazardous Substances Data: 137552-29-5(Hazardous Substances Data)

Upstream product

• 50-89-5 thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 72274-20-5 3′,5′-di-O-acetyl-5-azidomethyl-2′-deoxyuridine 
• 59090-48-1 5-(azidomethyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1370546-07-8 5-(N-trifluoroacetamidomethyl)-2'-deoxy-3'-O-succinyl-5'-O-(4,4'-dimethoxytrityl)uridine 
• 1370546-06-7 5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethoxy-N,N'-diisopropylaminophosphinyl)uridine 
• 1370546-05-6 5-(N-trifluoroacetamidomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 137568-57-1 5-(aminomethyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 886578-12-7 6-[3-O-(tert-butyl(dimethyl)silyl)-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3,4-dihydropyrimido[4,5-d]pyrimidine-2,7(1H,6H)-dione 
• 823791-02-2 3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxycytidine 
• 886578-13-8 6-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3,4-dihydropyrimido[4,5-d]pyrimidine-2,7(1H,6H)-dione 
• 823791-01-1 3'-O-(tert-butyl(dimethyl)silyl)-5'-O-(4,4'-dimethoxytrityl)-5-(azidomethyl)deoxyuridine 

Relevant articles and documents

Synthesis and properties of a new fluorescent bicyclic 4-N- carbamoyldeoxycytidine derivative

A bicyclic 4-N-carbamoyldeoxycytidine derivative (1, dChpp) geometrically locked was synthesized as a new fluorescent nucleobase. The hybridization properties of oligodeoxynucleotides containing dChpp were investigated by use of Tsu

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2′-Amino-LNA Monomers

Galactose-modified thymidine, LNA-T, and 2′-amino-LNA-T nucleosides were synthesized, converted into the corresponding phosphoramidite derivatives and introduced into short oligonucleotides. Compared to the unmodified control strands, the galactose-modified oligonucleotides in general, and the N2′-functionalized 2′-amino-LNA derivatives in particular, showed improved duplex thermal stability against DNA and RNA complements and increased ability to discriminate mismatches. In addition, the 2′-amino-LNA-T derivatives induced remarkable 3′-exonuclease resistance. These results were further investigated using molecular modeling studies.

Double-stranded oligonucleotides containing 5-aminomethyl-2′- deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA

This Letter describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stra