137553-19-6Relevant articles and documents
Acylation of novobiocin by carboxylic acid anhydrides: Preparation and characterization of semi-synthetic novenamines
Berkov-Zrihen, Yifat,Rutenberg, Roi,Fridman, Micha
scheme or table, p. 2306 - 2312 (2012/04/04)
The acylation of novobiocin by carboxylic acid anhydrides leading to preparation of three families of semi-synthetic acylated novenamine analogues is reported. ESI-MS was used to monitor the reaction progress and enabled the isolation of intermediate compounds that provided insights into the sequence of acylation steps during the reaction. The chemoselectivity of the reaction depends on the carboxylic acid anhydride. The potential of the acylated novenamine analogues as leads for the development of antibacterial agents is discussed.