137553-43-6 Usage
General Description
7-Bromo-2,4-diaminoquinazoline is a chemical compound with the molecular formula C8H6BrN5. It is a brominated derivative of 2,4-diaminoquinazoline, which is a key intermediate in the synthesis of certain pharmaceuticals. This chemical is known for its potential applications in medicinal chemistry and drug discovery, particularly in the development of kinase inhibitors and other bioactive compounds. It is a white to off-white solid that is sparingly soluble in water but soluble in organic solvents. Its precise properties and uses are the subject of ongoing research and development in the field of pharmaceutical chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 137553-43-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,5 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 137553-43:
(8*1)+(7*3)+(6*7)+(5*5)+(4*5)+(3*3)+(2*4)+(1*3)=136
136 % 10 = 6
So 137553-43-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrN4/c9-4-1-2-5-6(3-4)12-8(11)13-7(5)10/h1-3H,(H4,10,11,12,13)
137553-43-6Relevant articles and documents
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines
Li, Xiaoming,Hilgers, Mark,Cunningham, Mark,Chen, Zhiyong,Trzoss, Michael,Zhang, Junhu,Kohnen, Lucy,Lam, Thanh,Creighton, Chris,Gc, Kedar,Nelson, Kirk,Kwan, Bryan,Stidham, Mark,Brown-Driver, Vickie,Shaw, Karen J.,Finn, John
scheme or table, p. 5171 - 5176 (2011/10/09)
Dihydrofolate reductase (DHFR) inhibitors such as trimethoprim (TMP) have long played a significant role in the treatment of bacterial infections. Not surprisingly, after decades of use there is now bacterial resistance to TMP and therefore a need to develop novel antibacterial agents with expanded spectrum including these resistant strains. In this study, we investigated the optimization of 2,4-diamnoquinazolines for antibacterial potency and selectivity. Using structure-based drug design, several 7-aryl-2,4- diaminoquinazolines were discovered that have excellent sub-100 picomolar potency against bacterial DHFR. These compounds have good antibacterial activity especially on gram-positive pathogens including TMP-resistant strains.
