137553-48-1 Usage
Uses
Used in Pharmaceutical Industry:
4-AMINO-5-FLUOROQUINAZOLINE is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its potential applications include the development of anti-cancer, anti-bacterial, and anti-inflammatory drugs. The fluorine substitution in the quinazoline structure aids in achieving these therapeutic effects.
Used in Anti-Cancer Drug Development:
4-AMINO-5-FLUOROQUINAZOLINE is used as a key component in the development of anti-cancer drugs. Its unique structure and properties enable the design of drugs that can target and inhibit specific cancer-related pathways, leading to the suppression of tumor growth and progression.
Used in Anti-Bacterial Drug Development:
4-AMINO-5-FLUOROQUINAZOLINE is utilized as a building block in the creation of anti-bacterial drugs. Its structure allows for the development of compounds that can effectively target and eliminate bacterial infections, contributing to the treatment of various bacterial diseases.
Used in Anti-Inflammatory Drug Development:
4-AMINO-5-FLUOROQUINAZOLINE is employed as a component in the synthesis of anti-inflammatory drugs. Its properties enable the design of compounds that can modulate inflammatory responses, providing relief from inflammation and associated symptoms.
Used in Agrochemical Development:
4-AMINO-5-FLUOROQUINAZOLINE may have potential applications in the development of agrochemicals. Its unique structure and properties could be harnessed to create compounds that can protect crops from pests and diseases, contributing to increased agricultural productivity.
Used in Materials Science:
4-AMINO-5-FLUOROQUINAZOLINE may also find use in materials science. Its properties could be utilized in the development of new materials with specific characteristics, such as improved stability, enhanced binding capabilities, or other desirable traits for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 137553-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,5 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137553-48:
(8*1)+(7*3)+(6*7)+(5*5)+(4*5)+(3*3)+(2*4)+(1*8)=141
141 % 10 = 1
So 137553-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FN3/c9-5-2-1-3-6-7(5)8(10)12-4-11-6/h1-4H,(H2,10,11,12)
137553-48-1Relevant academic research and scientific papers
Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.
, p. 1357 - 1364 (2007/10/02)
Recently, we reported that appropriately substituted 2-fluorobenzonitriles undergo cyclization with guanidine carbonate to afford 2,4-diaminoquinazolines usually in good to excellent yield.This paper describes the preparation of a variety of new 2,4-diaminoquinazolines substituted at positions five or seven.In addition, the reactions of selected 2-fluorobenzonitriles with formamidine acetate or acetamidine acetate were examined.The results obtained demonstrate that the analogous 4-amino- and 2-methyl-4-aminoquinazolines can be prepared by this approach but that yields are considerably lower than when guanidine carbonate is employed as the cyclization reagent.
