1375645-00-3Relevant academic research and scientific papers
Toward the total synthesis of Luminamicin: Construction of 14-membered lactone framework possessing versatile enol ether moiety
Kimishima, Aoi,Hirose, Tomoyasu,Sugawara, Akihiro,Matsumaru, Takanori,Nakamura, Kaoru,Katsuyama, Ken,Toda, Masaki,Takada, Hirokazu,Masuma, Rokuro,Omura, Satoshi,Sunazuka, Toshiaki
, p. 2813 - 2816 (2012/07/28)
Luminamicin (1) was found to exhibit selective antibacterial activity against anaerobic bacteria by our group in 1985. The concise structure of 14-membered lactone of 1 was synthesized. Construction of a versatile enol ether moiety was achieved by Stille cross coupling via hydrostanylation of the ethynyl ether, and a maleic anhydride moiety was derived from the furan constitution by the oxidation after the macrolactonization at a late-stage.
