1375744-31-2Relevant academic research and scientific papers
Traceless directing group for stereospecific nickel-catalyzed alkyl-alkyl cross-coupling reactions
Greene, Margaret A.,Yonova, Ivelina M.,Williams, Florence J.,Jarvo, Elizabeth R.
, p. 4293 - 4296 (2012/09/22)
Stereospecific nickel-catalyzed cross-coupling reactions of benzylic 2-methoxyethyl ethers are reported for the preparation of enantioenriched 1,1-diarylethanes. The 2-methoxyethyl ether serves as a traceless directing group that accelerates cross-coupling. Chelation of magnesium ions is proposed to activate the benzylic C-O bond for oxidative addition.
