1375744-63-0

Basic information

• Product Name: 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione
• Synonyms: 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione
• CAS NO: 1375744-63-0
• Molecular Weight: 322.364
• Mol File: 1375744-63-0.mol

Chemical Properties

• CAS DataBase Reference: 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione(1375744-63-0)
• EPA Substance Registry System: 3-benzoyl-4-benzyl-1-methylpiperazine-2,5-dione(1375744-63-0)

Safety Data

• Hazardous Substances Data: 1375744-63-0(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 1375744-61-8 phenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]-methyl}-N-methylcarbamate 
• 1375744-62-9 phenyl N-{[benzyl(2-oxo-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate 
• 1375744-84-5 4-nitrophenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate 
• 1375744-64-1 4-nitrophenyl N-{[benzyl(2-oxo-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate 
• 51096-49-2 2-benzylamino-1-phenyl-ethanol 
• 100-46-9 benzylamine 

Relevant articles and documents

A Dieckmann cyclization route to piperazine-2,5-diones

Piperazine-2,5-diones are formed by Dieckmann cyclization (NaH, THF) of substructures of the type CH2-N(R)C(O)CH2N(R′) CO2Ph in which the terminal methylene (CH2) that is adjacent to nitrogen closes onto the carbonyl group of the phenyl carbamate unit at the other end of the chain. R and R′ are alkyl groups, and the terminal methylene is activated by a ketone carbonyl, a nitrile, an ester, or a phosphoryl group. The starting materials are assembled by standard acylation and oxidation processes, starting from a β-(alkylamino)alcohol, an (alkylamino)acetonitrile, an (alkylamino) ester, or an (alkylamino)methyl phosphonate.