137592-43-9 Usage
Description
Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM.
Uses
Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,
Check Digit Verification of cas no
The CAS Registry Mumber 137592-43-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,9 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 137592-43:
(8*1)+(7*3)+(6*7)+(5*5)+(4*9)+(3*2)+(2*4)+(1*3)=149
149 % 10 = 9
So 137592-43-9 is a valid CAS Registry Number.
137592-43-9Relevant articles and documents
Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
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, (2008/06/13)
The present invention provides a method of inducing apoptosis in target cells of a subject by administering, to the subject a pharmaceutically effective amount of at least one compound of the formula: wherein: R1is hydrogen, C1-C12alkyl, C1-C12substituted alkyl, C3-C7heterocycle, or C3-C7substituted heterocycle, R2and R3are independently H or C1-C12alkyl, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein following the administration of the compound of Formula I, the target cell is caused to undergo apoptosis.
