1375958-75-0

Basic information

• Product Name: (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide
• Synonyms: (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide;1-Aza-4-azoniabicyclo[2.2.2]octan-4-ylsulfonyl-(tert-butoxycarbonyl)azanide
• CAS NO: 1375958-75-0
• Molecular Formula: C₁₁H₂₁N₃O₄S
• Molecular Weight: 291.37
• EINECS: -0
• Mol File: 1375958-75-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide(1375958-75-0)
• EPA Substance Registry System: (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide(1375958-75-0)

Safety Data

• Hazardous Substances Data: 1375958-75-0(Hazardous Substances Data)

Usage

Uses

(1,4-Diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide is a reagent in the preparing the tumor inhibitor MLN4924.

Upstream product

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 

Downstream Products

• 1160295-21-5 ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)-methyl sulfamate hydrochloride 
• 905579-51-3 ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)-methyl sulfamate 

Relevant articles and documents

N-(tert -butoxycarbonyl)- N -[(triethylenediammonium)sulfonyl]azanide: A convenient sulfamoylation reagent for alcohols

A convenient and efficient procedure is described for the sulfamoylation of alcohols using N-(tert-butoxycarbonyl)-N-[(triethylenediammonium)sulfonyl] azanide (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary > phenol > secondary ? tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.