137601-08-2Relevant articles and documents
Total synthesis of ciguatoxin and 51-hydroxyCTX3C
Inoue, Masayuki,Miyazaki, Keisuke,Ishihara, Yuuki,Tatami, Atsushi,Ohnuma, Yuyu,Kawada, Yuuya,Komano, Kazuo,Yamashita, Shuji,Lee, Nayoung,Hirama, Masahiro
, p. 9352 - 9354 (2006)
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers with the 13 ether rings ranging from five- to nine-membered. In this paper, we describe the total synthesis of the two most toxic members o
PROCESS FOR PRODUCING RADIOHALOGENATED BIOCONJUGATES AND PRODUCTS THEREOF
-
Paragraph 0257; 0258, (2013/08/28)
The present invention relates to a new synthetic process in which an alkyne and an azide react to form a radioisotopic bioconjugate construct. The reaction is particularly useful for producing compounds for use in imaging and radiotherapy applications. The present invention also provides bioconjugate labels and further relates to the use of these compounds in diagnostic and therapeutic methods. In addition, the invention provides a related process for introducing a radioisotopic halogen atom into a terminal alkyne.