137609-78-0

Upstream product

• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 147986-41-2 Ethyl (2E)-6-Bromo-2,6-heptadienoate 
• 137609-80-4 Ethyl (2E,4S,5S)-8-Bromo-4,5-epoxy-2,8-nonadienoate 
• 137609-81-5 Ethyl (2E,5S)-8-Bromo-5-hydroxy-2,8-nonadienoate 
• 137609-95-1 (2R,3S)-3-(3-Bromo-but-3-enyl)-oxirane-2-carbaldehyde 
• 137609-94-0 (2S,3S)-6-Bromo-2,3-epoxy-6-hepten-1-ol 
• 137609-79-1 (2E)-6-Bromo-2,6-heptadien-1-ol 
• 137609-77-9 Ethyl (2E,5S)-8-Bromo-5<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2,8-nonadienoate 

Downstream Products

• 137693-94-8 [(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methylene-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 81506-23-2 <3S-(1E,3α,5β)>-<3,5-bis<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>acetic acid ethyl ester 

Relevant academic research and scientific papers

Stereoselective Synthesis of 1α-Hydroxyvitamin D3 A-Ring Synthons by Palladium-Catalyzed Cyclization

Palladium-catalyzed cyclization of 8-bromo-2,8-nonadienoates proceeded stereoselectively to give 1α-hydroxyvitamin D3 A-ring synthons in good yields.

Asymmetric Synthesis of Vitamin D3 Analogues: Organocatalytic Desymmetrization Approach toward the A-Ring Precursor of Calcifediol

A novel asymmetric synthesis has been developed for the construction of the A-ring of a chiral precursor to calcifediol. The highlights of this synthesis include (i) the introduction of the stereochemistry at the C5-position of the A-ring through the orga

An Efficient Asymmetric Synthesis of 1α,25-(OH)2 Vitamin D3 A-Ring Synthon

Chiral synthesis of the A-ring synthon 3 of 1α,25-dihydroxyvitamin D3 (1a) based on palladium-catalyzed cyclization of 8-bromo-2,8-nonadienoates is described.Reaction of (E)-4b and (Z)-4d in the presence of Pd(OAc)2, PPh3 and K2CO3 gave (E)-3b and (Z)-3d, respectively.Optically active 4d was prepared from 24 by asymmetric aldol reaction using 31, which was cyclized to 3d.With further reactions, 1α,25-dihydroxyvitamin D3 (1a) was obtained.