137616-57-0

Upstream product

• 137616-56-9 (6S,7R)-2,2,4,4-Tetraisopropyl-6-((E)-styryl)-[1,3,5,2,4]trioxadisilocan-7-ol 
• 108-86-1 bromobenzene 
• 169526-37-8 (6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 75156-15-9 Methyl 4,6-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-dily)-α-D-glucopyranoside 

Downstream Products

• 95041-49-9 1',2'-dideoxy-β-1'-phenyl-D-ribofuranose 

Relevant academic research and scientific papers

Disiloxane-protected 2-deoxyribonolactone as an efficient precursor to 1,2-dideoxy-1-β-aryl-D-ribofuranoses

(matric presented) Aryl C-nucleosides are analogues of natural nucleosides where the bases have been replaced with aromatic moieties. Work herein describes the highly stereoselective syntheses of non-hydrogen-bonding carbocyclic derivatives using a disiloxane-protected 2-deoxy-D-ribono-1,4-lactone as a stable and readily accessible starting material. Unlike the bis(TBDMS)-protected congener, this compound enables the use of sterically congested ortho-substituted aryllithium reagents in the initial addition reaction.

ERYTHROSE SESQUI-ACETALS AS ELECTROPHILES. 2-DEOXY-C-NUCLEOSIDES FROM D-GLUCOSE.

Cleavage of glucosides with NaIO4 in MeOH furnishes sesqui-acetals (protected dialdehydes).Olefination of these substrates, followed by endocyclic oxymercuration-demercuration furnishes substituted tetrahydrofurans (1,2-dideoxy-1-aryl-D-ribofuranoses).Pro