137627-25-9

Upstream product

• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 137627-13-5 2-((E)-(R)-5-Methylsulfanyl-hex-3-enyloxy)-tetrahydro-pyran 
• 137627-12-4 Thioacetic acid S-[(E)-(R)-1-methyl-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyl] ester 
• 137694-50-9 (5S,3E)-1-<(tetrahydro-2H-pyran-2-yl)oxy>hex-3-en-5-ol 
• 137627-11-3 (5S,3E)-5-<(tert-butyldimethylsilyl)oxy>hex-3-en-1-ol 

Relevant academic research and scientific papers

Enantiospecific Synthesis of (-)-Tabtoxinine &β-Lactam

A convergent, 10-step synthesis of optically active tabtoxinine β-lactam has been described.Key features of the synthetic route include (1) preparation of a new γ-cation amino acid synthon, (-)-4, and its use as an electrophile (3 -> 11); (2) the one-pot conversion of methyl sulfide 11 to the Cbz-protected amine 12 via stereoselective sulfilimine rearrangement; and (3) chemoselective lactone ring opening in spiro lactam 15a.Synthons (-)-4 and 3 are available on a semipreparative scale.