137634-83-4Relevant academic research and scientific papers
Mannich condensations of activated cyclic enamines
Alekszi-Kaszás, Anna,Nemes, Péter,Tóth, Gábor,Halász, Judit,Scheiber, Pál
, p. 2099 - 2111 (2018)
The synthesis of Mannich compounds starting from activated enamines, i.e., 2-nitromethylene-pyrrolidine and pyrrolidin-2-ylidene-acetic acid ethyl ester, with various amines and formaldehyde or ethyl glyoxylate are described. In order to furnish new Mannich type molecules and to improve the yields sequential reaction routes and 1,2,3-benzotriazole-substituted adducts as reactants were also tested. Additionally, the steric structure of a tricyclic spiro compound formed unexpectedly in high yield was elucidated in details by modern NMR methods.
Studies on immunostimulating derivatives: Synthesis of some pyrrolo[1,2-c]pyrimidines
Bahaji,Tronche,Couquelet,Harraga,Panouse-Perrin,Rubat
, p. 2126 - 2128 (2007/10/02)
In a search for potential immunomodulating agents novel pyrrolo[1,2-c]pyrimidines were synthesized and their structures elucidated by spectroscopic means. Unfortunately, most of them were cytotoxic and devoid of effects on T lymphocyte lymphoblastic transformation. Furthermore, they were inactive in the locomotor activity test in mice.
