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Relevant academic research and scientific papers

A new and efficient procedure for Friedlaender synthesis of quinolines in low melting tartaric acid-urea mixtures

A general, efficient and green method for the synthesis of quinoline derivatives via the Friedlaender heteroannulation reaction of 2-aminoaryl ketones and α-methylene ketones has been developed, employing low melting mixtures of L-(+)-tartaric acid and ur

Tetrahydroacridines as corrosion inhibitor for X80 steel corrosion in simulated acidic oilfield water

X80 steel is commonly used in pipeline, tubing, casing and other facilities in oilfield construction. Its corrosion behaviors in 15% HCl without or with tetrahydroacridines was investigated by weight-loss tests, electrochemical techniques along with scann

Green synthesis method of tetrahydroacridine compound under promotion of iodine anion

The invention relates to a green synthesis method of tetrahydroacridine compound under promotion of iodine anions. The structure formula of the prepared tetrahydroacridine compound is shown in Figure1, wherein R1, R2, R3 and R4 are hydrogen atoms,alkyl gr

Effective and Sustainable Access to Quinolines and Acridines: A Heterogeneous Imidazolium Salt Mediates C–C and C–N Bond Formation

Quinoline and acridine derivatives have been prepared using a functionalized imidazolium salt as heterogeneous catalyst. Different ketones have been coupled with 2-aminobenzaldehydes and 2-aminoaryl ketones under solvent-free conditions, employing 1,3-bis(carboxymethyl)-imidazolium chloride as a catalyst. The protocol is simple and effective for the synthesis of a variety of nitrogen containing heterocycles (> 35 examples) with moderate to excellent yields (up to 96 %), being possible to perform the reaction in preparative scale. Additionally, 3-acetylquinolines have been transformed, under solvent-free conditions, into quinolyl chalcone derivatives by means of the same catalyst. Thus, the catalytic system mediates both reactions effectively in a tandem procedure. Furthermore, the catalyst is easily separated from the reaction mixture and can be reused without loss of activity (up to 8 cycles) which remarks its sturdiness. The E-factors are in the range of 14–23, both for the formation of quinolines and for the tandem reaction, which demonstrates the sustainability of the protocols described.

Versatile Barium and Calcium Imidazolium-Dicarboxylate Heterogeneous Catalysts in Quinoline Synthesis

This article details the development of heterogeneous catalysts based on calcium and barium in combination with the organic linker 1,3-bis(carboxymethyl)imidazolium (bcmim). The linker and the materials from alkaline earth metals are easily prepared under very smooth conditions. The use of linkers with different counterions (Cl or Br) provided different materials. Calcium- and barium-based catalysts were successfully employed in the preparation of quinoline derivatives from ketones and 2-aminoarylaldehydes or 2-aminoarylketones. In general, barium-based catalysts provided better results than calcium, although the latter are an excellent complement for certain substrates. Thus, a notable feature of such catalysts is the possibility of accessing a variety of complementary heterogeneous catalytic systems, rendering the catalysis adaptive to the reactant.||||||.

Friedl?nder annulation: Scope and limitations of metal salt Lewis acid catalysts in selectivity control for the synthesis of functionalised quinolines

The scope and limitations of metal salt Lewis acid catalysts were examined for the selectivity control for the formation of Friedl?nder and non-Friedl?nder products during the reaction involving 2-aminobenzophenone and ethyl acetoacetate. Among a pool of