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AM-1220 is a potent synthetic cannabinoid (CB) with a preference for the central CB1 receptor (Ki = 3.88 nM) over the CB2 receptor (Ki = 73.4 nM). It is a synthetic cannabimimetic indole derivative that acts as a potent and moderately selective agonist for the cannabinoid receptor CB1. The physiological actions and metabolism of AM-1220 have not been fully characterized.

137642-54-7

137642-54-7 Suppliers

This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn't provide relevant sales information.

137642-54-7 Usage

Uses

Used in Pharmaceutical Research:
AM-1220 is used as a research compound for studying the effects and interactions of the CB1 receptor. Its high selectivity for CB1 over CB2 makes it a valuable tool in understanding the role of these receptors in various physiological processes and potential therapeutic applications.
Used in Drug Development:
AM-1220 is used as a lead compound in the development of new drugs targeting the cannabinoid system. Its potent agonist activity at the CB1 receptor can be leveraged to develop medications for conditions such as pain, inflammation, and neurodegenerative diseases, among others.
Used in Neuroscience:
AM-1220 is used as a research tool in neuroscience to investigate the role of the endocannabinoid system in the central nervous system. This can help researchers better understand the mechanisms underlying various cognitive and emotional processes, as well as the potential therapeutic applications of modulating the CB1 receptor.
Used in Preclinical Studies:
AM-1220 is used in preclinical studies to evaluate its potential therapeutic effects and safety profile. These studies can provide valuable information on the efficacy, pharmacokinetics, and potential side effects of AM-1220, which can inform the design of future clinical trials and drug development efforts.

Check Digit Verification of cas no

The CAS Registry Mumber 137642-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,6,4 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 137642-54:
(8*1)+(7*3)+(6*7)+(5*6)+(4*4)+(3*2)+(2*5)+(1*4)=137
137 % 10 = 7
So 137642-54-7 is a valid CAS Registry Number.

137642-54-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (1-((1-Methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone

1.2 Other means of identification

Product number -
Other names [1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]-naphthalen-1-ylmethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137642-54-7 SDS

137642-54-7Downstream Products

137642-54-7Relevant academic research and scientific papers

Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography

Willis, Peter G.,Pavlova, Olga A.,Chefer, Svetlana I.,Vaupel, D. Bruce,Mukhin, Alexey G.,Horti, Andrew G.

, p. 5813 - 5822 (2007/10/03)

A new series of CB1 ligands with high binding affinity (K i = 0.7-100 nM) and moderate lipophilicity (cLogD7.4) in the range of 2.1-4.5 has been synthesized. A structure-activity relationship study demonstrated that for the studied set of aminoalkylindoles, the molecular dipole of the ground state conformation within the series was inversely related to the affinity. The racemic ligand with highest affinity (0.7 nM), 3-(4-fluoronaphthoyl)-1-(N-methylpiperidin-2-ylmethyl)indole, was radiolabeled with 18F. This radioligand specifically labeled CB1 receptors in mouse brain and accumulated in regions of high versus low CB 1 receptor density in a ratio of 1.6. The displaceable radioactivity of one enantiomer in the brains of mice determined in a pretreatment study using the CB1 antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) was nearly double that of the race-mate for the same determination; therefore, the active enantiomer is a candidate for PET studies in animals. A pretreatement study for the other enantiomer found no displaceable radioactivity in the same group of mice; this result suggested the enantiomer was inactive.

C-attached aminoalkylindoles: Potent cannabinoid mimetics

D'Ambra, Thomas E.,Eissenstat, Michael A.,Abt, Jeffrey,Ackerman, James H.,Bacon, Edward R.,Bell, Malcolm R.,Carabateas, Philip M.,Josef, Kurt A.,Kumar, Virendra,Weaver III, John D.,Arnold, Renee,Casiano, Frances M.,Chippari, Susan M.,Haycock, Dean A.,Kuster, Joan E.,Luttinger, Daniel A.,Stevenson, Joan I.,Ward, Susan J.,Hill, W. Adam,Khanolkar, Atmaram,Makriyannis, Alexandros

, p. 17 - 22 (2007/10/03)

Aminoalkylindoles (AAIs) with potent cannabinoid agonist activity have been synthesized where the aminoalkyl chain is attached to the indole ring via a carbon atom of the cyclic amine.