1376434-72-8Relevant academic research and scientific papers
Simple one-pot synthesis of new derivatives of the macrocyclic aminal 1,3,7,9,13,15,19,21-octaazapentacyclo-[19.3.1.13,7.1 9,13.115,19]octacosane (OAPO)
Rivera, Augusto,Ros-Motta, Jaime,Trujillo, Ginna Paola,González, Derly Marcela,Alcázar, Daniel
, p. 791 - 799 (2013/02/23)
A series of 2,2-(dihydropyrimidine-1,3(2H,4H)-diyldimethanediyl) bis(substituted-phenols) was synthesized using a Mannich-type reaction between the macrocyclic aminal 1,3,7,9,13,15,19,21-octaazapentacyclo[19.3.1.1 3,7.19,13.115,19]octacosane (OAPO) (1) and substituted phenols in basic media. These previously unreported compounds were separated from the reaction mixture by column chromatography in highly pure form with 25-75% yields. The most stable conformer was predicted using AM1-type semiempirical quantum chemical calculations.
